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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Cell-Based Drug Delivery and Use of Nano-and Microcarriers for Cell Functionalization.

Alexander S Timin1, Maxim M Litvak1, Dmitry A Gorin1,2,3

  • 1RASA Center in Tomsk, Tomsk Polytechnic University, pros. Lenina, 30, Tomsk, 634050, Russian Federation.

Advanced Healthcare Materials
|December 2, 2017
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Summary

Cell functionalization using nano- and microcarriers enhances cell therapy and targeted drug delivery. This review covers advances in cell-based drug vehicles for efficient disease treatment with minimal immune response.

Keywords:
animal modelscell therapydrug deliveryischemia reperfusionpolyelectrolyte and hybrid capsules

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Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Cell Therapy

Background:

  • Cellular functionalization with nano- and microcarriers has advanced cell therapy and drug delivery.
  • These advancements offer new strategies for treating various diseases effectively.

Purpose of the Study:

  • To review recent progress in cell-based drug vehicles for targeted drug delivery.
  • To explore cell functionalization methods and in vivo visualization techniques.

Main Methods:

  • Review of literature on cell functionalization pathways (covalent, noncovalent).
  • Discussion of carrier internalization strategies.
  • Analysis of in vivo cell visualization approaches.
  • Examination of animal models for cell-assisted drug delivery.

Main Results:

  • Recent advances in designing cell-based drug vehicles as biological transporter platforms.
  • Detailed consideration of cell functionalization techniques and in vivo tracking methods.
  • Evaluation of animal models for studying cell-assisted drug delivery efficacy.

Conclusions:

  • Cell-based drug vehicles show significant potential for targeted drug transport.
  • Future developments aim for minimal immune response and toxicity in nanomedicine applications.