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Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
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Diverse correlations between fibrosis-related factors and liver stiffness measurement by transient elastography in

Ziyu Lin, Jing Liang, Jianyun Zhu

    European Journal of Gastroenterology & Hepatology
    |December 2, 2017
    PubMed

    Insights

    Liver stiffness measurements in chronic hepatitis B (CHB) correlate differently with fibrosis markers in mild versus cirrhotic disease. These findings highlight stage-specific relationships for better disease assessment in CHB patients.

    Area of Science:

    • Hepatology
    • Medical Diagnostics
    • Fibrosis Research

    Background:

    • Liver stiffness measurements (LSM) are influenced by various fibrosis-related factors.
    • These influences have not been thoroughly studied across different stages of chronic hepatitis B (CHB).

    Purpose of the Study:

    • To investigate the relationship between fibrosis-related factors and LSM.
    • To compare these correlations across mild CHB and cirrhotic hepatitis B (cirrhotic HB) disease stages.

    Main Methods:

    • Compared mild CHB (n=305) and cirrhotic HB (n=137) patients.
    • Assessed correlations between LSM and liver inflammation markers (ALT, AST, Tbil), albumin, globulin, blood cell counts, and spleen parameters (SV, DS, TS).

    Main Results:

    • In mild CHB, LSM strongly correlated with ALT, AST, Tbil, albumin, albumin/globulin ratio, SV, DS, and spleen volume.
    • Red blood cells showed a negative correlation with LSM in both groups.
    • In cirrhotic HB, LSM only significantly correlated with Tbil, indicating weaker associations with other factors.

    Conclusions:

    • The correlation between fibrosis-related factors and LSM varies significantly between mild CHB and cirrhotic HB.
    • This suggests disease stage is a critical factor in interpreting LSM results for CHB.
    Abstract

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