Related Experiment Video
Updated: Feb 17, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Male Neonate with Legionellosis
Adam M Szewc1, Steve Taylor2, Gary D Cage1
1Microbiology/Molecular Department, Phoenix Children's Hospital, Phoenix, AZ.
Abstract:
Legionellaceae are composed of a single genus, Legionella, which is currently comprised of over 52 species. L. pneumophila, L. micdadei, L. longbeachae, and L. dumoffi are clinically considered the most important, with L. pneumophila causing >90%1,7 of cases of legionnaires disease (LD). Since LD's recognition in 1976 following an outbreak of pneumonia involving delegates of an American Legion convention in Philadelphia, there has been increased awareness and importance of the isolation, detection, and reporting of these cases. Herein we describe the unfortunate case of a 7 month old boy with undiagnosed LD that lead to respiratory insufficiency, sepsis, multisystem organ failure and death. Laboratory investigation methods, and clinical and pathological findings are discussed.
Related Concept Videos
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Bacterial Phylum Spirochaetes
Sexually Transmitted Infections

