Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ASO Visual Abstract: Long-Term Outcomes of Patients with Gastric Cancer and Positive Peritoneal Cytology.

Annals of surgical oncology·2026
Same author

Long-Term Outcomes of Patients with Gastric Cancer and Positive Peritoneal Cytology.

Annals of surgical oncology·2026
Same author

Genome sequences of seven <i>Streptomyces</i> isolates for genome prospecting.

Microbiology resource announcements·2026
Same author

Breaking the Immune Sanctuary: Targeting Metastatic Niches.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting·2026
Same author

Differential Responses of <i>Salmonella enterica</i> Typhimurium, <i>S. enteritidis</i>, and <i>S. infantis</i> to Chlorine Dioxide In Vitro: Impacts on Growth and Biofilm Development.

Microorganisms·2026
Same author

Regional expression of neurochemical metabolic pathways in the intestinal tract of the turkey (Meleagris gallopavo domesticus).

Poultry science·2026
Same journal

Institutional Learning Curve in Esophagectomy: Technical Standardization of Gastric Conduit Formation and Conduit-Related Outcomes in 187 Consecutive Patients.

Journal of surgical oncology·2026
Same journal

Evaluating the Accuracy of ChatGPT-4o in Addressing Complex Clinical Questions Based on NCCN Guidelines for Rectal Adenocarcinoma.

Journal of surgical oncology·2026
Same journal

Racial Differences in Breast Cancer Treatment and Information Access.

Journal of surgical oncology·2026
Same journal

Comparative Analysis of CEM and Breast MRI: A Retrospective Study.

Journal of surgical oncology·2026
Same journal

The Treatment Efficacy for Patients Undergoing Combined Transanal-Transabdominal Endoscopic Resection of Rectal Anastomosis Stenosis.

Journal of surgical oncology·2026
Same journal

"It Depends on the Situation": Variability in How Surgical Oncologists Elicit and Integrate Patient Values.

Journal of surgical oncology·2026
See all related articles

Related Experiment Video

Updated: Feb 17, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

21.6K

Transected thin melanoma: Implications for sentinel lymph node staging.

Garth Herbert1, Giorgos C Karakousis2, Edmund K Bartlett2

  • 1Department of Surgery, San Antonio Military Medical Center, San Antonio, Texas.

Journal of Surgical Oncology
|December 2, 2017
PubMed
Summary
This summary is machine-generated.

For thin melanoma patients, a positive deep margin on initial biopsy does not increase the risk of sentinel lymph node metastasis. Therefore, deep margin status alone should not guide sentinel lymph node staging decisions.

Keywords:
melanomasentinel lymph nodethintransected

More Related Videos

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.5K
DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
10:38

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

Published on: February 1, 2020

8.0K

Related Experiment Videos

Last Updated: Feb 17, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

21.6K
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.5K
DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
10:38

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

Published on: February 1, 2020

8.0K

Area of Science:

  • Dermatology
  • Surgical Oncology
  • Pathology

Background:

  • Sentinel lymph node (SLN) biopsy is a crucial staging procedure for melanoma.
  • Indications for SLN biopsy in thin melanomas (≤1 mm) remain controversial.
  • The association between deep margin (DM) status and SLN metastasis in thin melanoma requires further clarification.

Purpose of the Study:

  • To investigate whether a positive deep margin at initial biopsy of thin melanoma is associated with sentinel lymph node positivity.
  • To determine if DM status should be an indication for SLN staging in thin melanoma patients.

Main Methods:

  • Retrospective analysis of prospectively maintained databases from two melanoma centers.
  • Inclusion of patients with thin melanoma (≤1 mm) who underwent SLN biopsy.
  • Assessment of DM status and its association with SLN metastasis using univariate and multivariate analyses.

Main Results:

  • 1129 patients with known DM status were analyzed.
  • 39% of patients had a positive DM.
  • No significant difference in SLN metastasis incidence between DM-positive (5.7%) and DM-negative (3.5%) groups (P=0.07).
  • Positive DM was not significantly associated with SLN metastasis on univariate or multivariate analysis.

Conclusions:

  • A positive deep margin on initial biopsy is not associated with an increased risk of sentinel lymph node metastasis in patients with thin melanoma.
  • Deep margin positivity should not be considered an indication for SLN staging in otherwise low-risk thin melanoma patients.