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Related Experiment Videos

Radiation therapy-associated invasive bladder tumors.

A Sella1, F H Dexeus, C Chong

  • 1Division of Medicine, University of Texas M. D. Anderson Cancer Center, Houston.

Urology
|March 1, 1989
PubMed
Summary

Radiotherapy for urothelial carcinoma can lead to bladder cancer, diagnosed on average 20.5 years later. Early symptoms include gross hematuria, with outcomes varying significantly post-diagnosis.

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Area of Science:

  • Urology
  • Oncology
  • Radiation Oncology

Background:

  • Advanced urothelial carcinoma often requires radiotherapy.
  • Secondary malignancies, including bladder cancer, are a known risk of radiation treatment.
  • Understanding the incidence and characteristics of radiotherapy-associated bladder carcinoma is crucial for patient monitoring.

Purpose of the Study:

  • To determine the incidence of bladder carcinoma in patients previously treated for advanced urothelial carcinoma.
  • To characterize the clinical presentation, histology, and outcomes of radiotherapy-associated bladder carcinoma.

Main Methods:

  • Retrospective analysis of 244 cases of advanced urothelial carcinoma.
  • Identification of patients who developed bladder carcinoma post-radiotherapy.

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  • Review of patient demographics, treatment history, tumor characteristics, and survival data.

    • Main Results:

    • Radiotherapy-associated bladder carcinoma occurred in 3.7% of patients.
    • The average age at diagnosis was 63.1 years, with a mean latency of 20.5 years post-radiation.
    • Gross hematuria was the primary presenting symptom; transitional cell carcinoma with vascular/lymphatic invasion was common.
    • Mean survival was 15.4 months, with a 55.5% one-year disease-free survival rate.

    Conclusions:

    • Radiotherapy for advanced urothelial carcinoma is associated with a notable risk of secondary bladder cancer.
    • Delayed diagnosis is common, often presenting with hematuria.
    • Prognosis is variable, highlighting the need for long-term surveillance in this patient population.