Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anatomy of the Circulatory System

Anatomy of the Circulatory System

The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.

Overview of Anatomy and Physiology

Overview of Anatomy and Physiology

Human anatomy is the scientific study of the body's structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word "anatomy" comes from a Greek root that means "to cut apart." Human anatomy was first studied by observing the body's exterior and the wounds of soldiers and other injuries. Later, physicians were allowed to...

Fetal Circulation

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

Gross Anatomy of the Lungs

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...

Liver Physiology

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...

Atelectasis II: Pathophysiology

Atelectasis II: Pathophysiology

Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clock gene signature predicts insomnia and links to sleep/circadian parameters.

Translational psychiatry·2026

Same author

Quantifying sleep wake rhythms in the hospital environment with digital technologies.

NPJ digital medicine·2026

Same author

Glucose is dynamically regulated by time of day in humans and Drosophila.

PLoS biology·2026

Same author

Endocytosis at the mouse blood brain barrier is elevated during sleep.

bioRxiv : the preprint server for biology·2026

Same author

Sleep-dependent clearance of brain lipids by peripheral blood cells.

Nature·2026

Same author

RNAi-based screen for pigmentation in <i>Drosophila melanogaster</i> reveals regulators of brain dopamine and sleep.

iScience·2026

Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026

Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026

Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026

Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026

Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026

Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 1, 2026

The FlyBar: Administering Alcohol to Flies

The FlyBar: Administering Alcohol to Flies

Published on: May 18, 2014

Physiology Flies with Time.

¹Chronobiology Program, HHMI, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

|December 2, 2017

Summary

This summary is machine-generated.

Nobel Prize winners discovered the molecular basis of the circadian clock. These biological rhythms influence nearly all life processes and are linked to human health and disease.

More Related Videos

A Computational Method to Quantify Fly Circadian Activity

A Computational Method to Quantify Fly Circadian Activity

Published on: October 28, 2017

An Automated Method to Determine the Performance of Drosophila in Response to Temperature Changes in Space and Time

An Automated Method to Determine the Performance of Drosophila in Response to Temperature Changes in Space and Time

Published on: October 12, 2018

Related Experiment Videos

Last Updated: May 1, 2026

The FlyBar: Administering Alcohol to Flies

The FlyBar: Administering Alcohol to Flies

Published on: May 18, 2014

A Computational Method to Quantify Fly Circadian Activity

A Computational Method to Quantify Fly Circadian Activity

Published on: October 28, 2017

An Automated Method to Determine the Performance of Drosophila in Response to Temperature Changes in Space and Time

An Automated Method to Determine the Performance of Drosophila in Response to Temperature Changes in Space and Time

Published on: October 12, 2018

Area of Science:

Chronobiology
Molecular Biology
Genetics

Background:

The 2017 Nobel Prize in Physiology or Medicine recognized foundational research into the molecular mechanisms governing circadian rhythms.
Early studies, primarily using fruit fly models, were crucial in deciphering these internal biological clocks.

Discussion:

Circadian regulation impacts a vast array of biological processes across diverse organisms.
Understanding these molecular mechanisms is vital for comprehending physiological functions and disease pathologies.

Key Insights:

Identified key genes and proteins controlling the circadian clock's molecular feedback loop.
Demonstrated the universality of these mechanisms across species, from insects to humans.

Outlook:

Further research into circadian clock disruptions may reveal new therapeutic targets for sleep disorders, metabolic diseases, and cancer.
The elucidation of circadian mechanisms opens avenues for optimizing human health through light exposure and sleep hygiene.