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Updated: Feb 17, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Epsin-Dependent Ligand Endocytosis Activates Notch by Force

Paul D Langridge1, Gary Struhl1

  • 1Department of Genetics and Development, Columbia University, New York, NY, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA.

Cell
|December 2, 2017
PubMed
Summary

Notch receptor activation requires DSL ligand endocytosis by Epsin, supporting "pulling" models over "recycling" models. Ligand endocytosis after Notch binding is crucial for cleavage and signal transmission.

Keywords:
DSL/Notch signalingNotchclathrindeltaendocytosisepsinforcevon Willebrand factor

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