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Prenatal and pubertal testosterone affect brain lateralization.

T Beking1, R H Geuze1, M van Faassen2

  • 1University of Groningen, Faculty of Behavioural and Social Sciences, Department Clinical & Developmental Neuropsychology, Grote Kruisstraat 2/1, 9712 TS Groningen, The Netherlands.

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|December 2, 2017
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Summary
This summary is machine-generated.

Prenatal and pubertal testosterone levels interact to influence brain lateralization in adolescent boys for specific tasks. This suggests complex, task-dependent hormonal effects on cognitive functions.

Keywords:
Brain asymmetryCognitive functionFTCDLateralityPubertySex hormones

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Developmental Psychology

Background:

  • The impact of prenatal testosterone on brain lateralization remains unclear.
  • The role of pubertal testosterone in functional brain lateralization is largely unexplored despite evidence of its effects on the brain during puberty.

Purpose of the Study:

  • To investigate the relationship between prenatal and pubertal testosterone concentrations and brain lateralization.
  • To examine task-specific effects on cognitive functions like Mental Rotation, Chimeric Faces, and Word Generation.

Main Methods:

  • Longitudinal study involving 30 boys and 30 girls at age 15.
  • Measured prenatal testosterone in amniotic fluid and pubertal testosterone in saliva.
  • Assessed brain lateralization using functional Transcranial Doppler Ultrasonography (fTCD) for specific tasks.

Main Results:

  • Significant interaction between prenatal and pubertal testosterone on lateralization for Mental Rotation and Chimeric Faces in boys.
  • In boys, pubertal testosterone showed differential relationships with lateralization strength based on prenatal testosterone levels.
  • Pubertal testosterone negatively related to left-hemisphere lateralization for Word Generation in boys.

Conclusions:

  • Prenatal and pubertal testosterone interact to influence brain lateralization in a task-specific manner in adolescent boys.
  • Findings challenge simple models of prenatal testosterone effects and suggest age-dependent hormonal influences.
  • Alternative models involving androgen receptor distribution and efficiency are proposed.