Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting Renal Tumor Pathology From Intraoperative Gross Appearance: An AI-Based Pilot Study.

Urology·2026
Same author

Evaluation of algorithms for predicting new baseline renal function after complex partial nephrectomy for multifocal renal tumors.

Urologic oncology·2026
Same author

Belzutifan efficacy in von Hippel-Lindau disease-associated renal cell carcinoma versus natural history control arm.

Journal of the National Cancer Institute·2026
Same author

Reply to Editorial Comment on "Unraveling Smooth Muscle-rich Renal Cell Carcinoma: Clinical, Oncological, Genetic, and Pathological Insights".

Urology·2026
Same author

Unraveling Smooth Muscle-rich Renal Cell Carcinoma: Clinical, Oncological, Genetic, and Pathological Insights.

Urology·2025
Same author

Multigenerational VHL family characterized by pathogenic germline ELOC variant: Response to belzutifan.

Urologic oncology·2025

Related Experiment Video

Updated: Feb 17, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

9.3K

Margin Assessment in Renal Surgery Using a Handheld Optical Coherence Tomography Probe.

Wesley W Ludwig1, Sara E Wobker2, Mark W Ball1

  • 1The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD.

Urology
|December 3, 2017
PubMed
Summary
This summary is machine-generated.

Handheld optical coherence tomography (OCT) accurately assessed surgical margins during partial nephrectomy (PN) ex vivo. This technology shows promise in reducing the need for frozen sections and minimizing tissue removal.

More Related Videos

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.3K
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

2.1K

Related Experiment Videos

Last Updated: Feb 17, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

9.3K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.3K
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

2.1K

Area of Science:

  • Urology
  • Surgical Oncology
  • Medical Imaging

Background:

  • Accurate assessment of surgical margins is critical in partial nephrectomy (PN) to ensure complete tumor removal.
  • Intraoperative margin evaluation often relies on frozen section analysis, which can be time-consuming and may not always be definitive.

Purpose of the Study:

  • To evaluate the feasibility and accuracy of a handheld optical coherence tomography (OCT) probe for intraoperative surgical margin assessment during PN.
  • To determine if OCT can reliably differentiate between positive and negative margins in kidney tumor specimens.

Main Methods:

  • A feasibility study involved sectioning a radical nephrectomy specimen with known gross margin widths (0, 1, and 2 mm).
  • Optical coherence tomography (OCT) was used to measure margin widths in these sections.
  • A prospective ex vivo study assessed 15 PN tumor specimens using OCT to determine margin status and measure tissue attenuation coefficients.

Main Results:

  • OCT measurements closely correlated with gross margin widths, with statistically significant differences between groups (P < .04).
  • The sensitivity and specificity of OCT for identifying positive margins were both 100%.
  • In ex vivo PN specimens, OCT accurately identified all negative margins.

Conclusions:

  • Handheld OCT is a feasible tool for ex vivo assessment of surgical margins in PN.
  • OCT has the potential to reduce the reliance on intraoperative frozen sections.
  • This technology may help surgeons minimize parenchymal excision while ensuring oncologic safety.