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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different
B Burja1, T Kuret1, S Sodin-Semrl2
1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana SI-1000, Slovenia.
Insights
Giant cell arteritis (GCA) lacks reliable serological markers for monitoring. This review identifies promising biomarkers by analyzing study data and meta-analysis to aid early diagnosis and prevent complications.
Area of Science:
- Immunology
- Rheumatology
- Internal Medicine
Background:
- Giant cell arteritis (GCA) is a vasculitis affecting older adults, primarily large and medium arteries.
- Early GCA diagnosis is critical to prevent severe outcomes like vision loss and stroke.
- Current monitoring lacks reliable serological markers.
Purpose of the Study:
- To review published GCA studies.
- To identify significantly changed serological biomarkers in GCA.
- To evaluate marker detection techniques and investigate promising markers using analyte frequency and meta-analysis.
Main Methods:
- Systematic review of published GCA studies.
- Analysis of serological biomarker changes.
- Comparison of different marker evaluation techniques.
- Meta-analysis and analyte frequency assessment for marker identification.
Main Results:
- Identification of specific serological biomarkers significantly altered in GCA.
- Evaluation of how different detection techniques impact biomarker results.
- Determination of the most promising biomarkers based on frequency and meta-analysis.
Conclusions:
- Existing GCA research highlights several potential serological biomarkers.
- Further investigation is needed to validate these markers for reliable GCA monitoring.
- Standardized techniques are crucial for consistent biomarker evaluation in GCA.
Abstract:
Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.
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