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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Related Experiment Video

Updated: Feb 17, 2026

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Coagulation Factor Hyperfunction After Subarachnoid Hemorrhage Induces Deep Venous Thrombosis.

Wang Miao1, Ke Zhao1, Wenjing Deng1

  • 1First Affiliated Hospital of Zhengzhou University, Department of Neurology, Zhengzhou, People's Republic of China.

World Neurosurgery
|December 3, 2017
PubMed
Summary

Subarachnoid hemorrhage (SAH) within 3 days can cause coagulation disorders, increasing deep venous thrombosis (DVT) risk. A specific thrombelastography value (R=3.65 minutes) may predict DVT in SAH patients.

Keywords:
Activated protein CCoagulation functionSubarachnoid hemorrhageThrombelastographyTissue factorTissue factor pathway inhibitor

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Area of Science:

  • Neuroscience
  • Hematology
  • Medical Diagnostics

Background:

  • Subarachnoid hemorrhage (SAH) is a critical neurological condition.
  • Coagulation dysfunction is a known complication following SAH.
  • Deep venous thrombosis (DVT) is a significant risk in SAH patients.

Purpose of the Study:

  • To investigate coagulation function changes within 3 days of SAH onset.
  • To explore mechanisms linking coagulation disorders and DVT post-SAH.
  • To identify potential biomarkers for DVT risk in SAH patients.

Main Methods:

  • Recruited 150 SAH patients and 100 healthy controls.
  • Utilized thrombelastography and laboratory tests for coagulation analysis.
  • Measured tissue factor (TF), tissue factor pathway inhibitor (TFPI), and activated protein C (APC) levels.

Main Results:

  • SAH patients showed decreased R values (coagulation function indicator) and increased TF, decreased TFPI.
  • R values correlated negatively with TF and positively with TFPI and APC.
  • An R value cutoff of 3.65 minutes was identified for DVT risk prediction in SAH.

Conclusions:

  • Coagulation hyperfunction and TF-TFPI-APC imbalance may contribute to DVT post-SAH.
  • Early identification of coagulation changes is crucial for DVT prevention.
  • The R value of 3.65 minutes serves as a potential threshold for DVT risk intervention.