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Modern iron replacement therapy: clinical and pathophysiological insights
Domenico Girelli1, Sara Ugolini2, Fabiana Busti2
1Department of Medicine, Section of Internal Medicine, Veneto Region Referral Center for Iron Metabolism Disorders, Center of Excellence for Rare Hematological Diseases "EuroBloodNet", University of Verona, Policlinico G.B. Rossi, 37134, Verona, Italy. domenico.girelli@univr.it.
International Journal of Hematology
|December 3, 2017
Summary
Iron deficiency treatment is evolving due to new insights into iron metabolism and improved drug formulations. Newer therapies address limitations of older iron replacement methods, enhancing patient care.
Area of Science:
- Hematology and Nutritional Science
- Pharmacology and Drug Development
Background:
- Iron deficiency, with or without anemia, is a significant global public health issue.
- Traditional oral and intravenous iron therapies have limitations regarding tolerability and safety.
Purpose of the Study:
- To review advancements in iron therapy driven by new understanding of iron metabolism.
- To discuss how pharmaceutical technology is improving iron formulations.
Main Methods:
- Review of recent scientific literature on iron metabolism and pharmacology.
- Analysis of the impact of the hepcidin/ferroportin axis on iron homeostasis.
- Comparison of pharmacokinetic profiles of traditional and novel iron formulations.
Main Results:
- The discovery of the hepcidin/ferroportin axis has transformed understanding of iron pathophysiology.
- Newer iron formulations aim to overcome the drawbacks of older treatments.
- Pharmacokinetics of oral and parenteral iron differ significantly, influenced by hepcidin.
Conclusions:
- Iron therapy is undergoing a significant transformation due to progress in pathophysiology and pharmacology.
- Understanding the hepcidin/ferroportin axis is crucial for developing better iron replacement strategies.
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