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Analyzing Trophoblast Function Using Cell-Based Assays.

Katie L Powell1,2,3, Anthony W Ashton4,5

  • 1Division of Perinatal Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia. katie.powell@sydney.edu.au.

Methods in Molecular Biology (Clifton, N.J.)
|December 3, 2017
PubMed
Summary

Functional cell-based assays help study placental cell functions. These assays can reveal how preeclampsia affects trophoblast cells and identify molecular pathways involved.

Keywords:
AdhesionApoptosisCell linesInvasionMigrationProliferationTrophoblasts

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Area of Science:

  • Reproductive biology
  • Cell biology
  • Pathology

Background:

  • Functional cell-based assays are vital for evaluating treatment effects on cultured cells.
  • Cell lines serve as models for normal biological processes and diseases.
  • Trophoblast cells are crucial for placental development, involving proliferation, differentiation, migration, and invasion.

Purpose of the Study:

  • To highlight the utility of functional cell-based assays in studying trophoblast cells.
  • To investigate impaired trophoblast functions in preeclamptic pregnancies.
  • To utilize cell-based assays for measuring differences and dissecting molecular pathways in preeclampsia.

Main Methods:

  • Employing functional cell-based assays.
  • Utilizing cell line models.
  • Analyzing trophoblast cell functions (proliferation, differentiation, migration, invasion).

Main Results:

  • Preeclampsia is associated with impaired trophoblast functions.
  • Functional cell-based assays can detect these functional impairments.
  • These assays aid in dissecting the molecular mechanisms underlying preeclampsia.

Conclusions:

  • Functional cell-based assays are valuable tools for preeclampsia research.
  • These assays enable the study of molecular regulatory pathways affected by preeclampsia.
  • Understanding these pathways can lead to better insights into placental dysfunction.