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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
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Pyelonephritis in Dogs: Retrospective Study of 47 Histologically Diagnosed Cases (2005-2015).
J Bouillon1, E Snead1, J Caswell2
1Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Journal of Veterinary Internal Medicine
|December 3, 2017
Summary
Pyelonephritis in dogs is uncommon in referral hospitals, presenting with vague symptoms and often co-occurring with other diseases. Diagnosis can be challenging due to variable test results and nonspecific clinical signs.
Area of Science:
- Veterinary Medicine
- Canine Pathology
- Infectious Diseases
Background:
- Clinicopathologic aspects of pyelonephritis in companion animals remain underreported.
- This study addresses the knowledge gap regarding canine pyelonephritis.
Purpose of the Study:
- To determine the prevalence of pyelonephritis in a canine referral population.
- To characterize clinical signs, diagnostic findings, and concurrent diseases associated with canine pyelonephritis.
- To identify potential risk factors for pyelonephritis in dogs.
Main Methods:
- A retrospective case series involving 47 dogs with histopathologic confirmation of pyelonephritis.
- Data were collected from medical records and renal histologic sections at three Canadian veterinary colleges.
Main Results:
- Pyelonephritis was diagnosed in 0.4-1.3% of necropsy cases.
- Common clinical signs included anorexia (57%), lethargy (51%), and vomiting (36%).
- Escherichia coli was the most frequent pathogen (37%), and 75% of dogs had concurrent diseases.
Conclusions:
- Canine pyelonephritis has a low necropsy prevalence in referral settings.
- Antemortem diagnosis is challenging due to nonspecific signs and variable test results.
- Only subacute pyelonephritis showed a significant association with fever.
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