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Updated: Feb 17, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography
Nikolaj Ørntoft1, Kim Frisch2, Peter Ott1
1Department of Hepatology & Gastroenterology, Aarhus University Hospital, Denmark.
Abstract:
Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.
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