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Echocardiography as the first diagnostic clue to rapidly progressive systemic AL amyloidosis associated with multiple

Bogdan Caloian1, Dumitru Zdrenghea2, Sorin Claudiu Man3

  • 1Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca. bogdan912@yahoo.com.

Medical Ultrasonography
|December 4, 2017
PubMed

Insights

AL-amyloidosis is a severe heart disease. Advanced echocardiography, including tissue Doppler imaging and speckle tracking, aids in diagnosing cardiac involvement and predicting outcomes in AL-amyloidosis patients.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Diagnostics

Background:

  • AL-amyloidosis is a rare systemic disease with a poor prognosis, frequently affecting the heart.
  • Cardiac involvement in AL-amyloidosis significantly worsens patient outcomes.
  • Rapidly increasing left ventricular (LV) wall thickness is a marker of unfavorable prognosis.

Observation:

  • A 63-year-old male patient with AL-amyloidosis and cardiac involvement was diagnosed.
  • The patient also presented with thrombosis at multiple sites.
  • Echocardiographic techniques were employed for detailed cardiac assessment.

Findings:

  • Tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) were utilized.
  • These advanced echocardiographic methods provided critical diagnostic insights.
  • The findings indicated the prognostic value of these techniques in cardiac AL-amyloidosis.

Implications:

  • Advanced echocardiography offers crucial diagnostic and prognostic information for AL-amyloidosis.
  • These techniques can improve the management of patients with cardiac involvement.
  • Further research into echocardiographic markers may refine risk stratification in AL-amyloidosis.

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