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A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Agelamasines A and B, diterpene alkaloids from an Okinawan marine sponge Agelas sp
Sanghoon Lee1, Naonobu Tanaka2,3, Jun'ichi Kobayashi4
1Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Abstract:
Two new diterpene alkaloids having an N-methyladenine moiety, agelamasines A (1) and B (2), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses. Agelamasine A (1) is the first diterpene alkaloid with a rearranged (4 → 2)-abeo-clerodane skeleton from a marine source, while agelamasine B (2) is a clerodane diterpene alkaloid.
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