Clinicopathologic features of solid pseudopapillary pancreatic neoplasms in an Eastern Caribbean population

Pancreatic solid pseudopapillary neoplasms (SPNs) are uncommon lesions across the globe. Their incidence is unknown in the Caribbean. This retrospective study sought to document the clinicopathologic features of pancreatic SPNs in an Eastern Caribbean population. We examined data from the hospital records of all patients with SPN in Trinidad and Tobago, finding 11 cases over five years, equating to an incidence of 0.17 cases per 100,000 population per year. The lesions occurred in girls and young women at a mean age of 25 years, with a propensity for those of Afro-Caribbean descent. Poor prognostic factors (histologic invasion of the capsule, lymphovascular invasion, spindle cells, anaplastic cells and/or excessive mitotic figures) were present in 82% at the time of diagnosis. These tumours are uncommon in our population, and since most have poor prognostic features at diagnosis, we advocate an aggressive surgical approach.