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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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Emerging roles for long noncoding RNAs in B-cell development and malignancy.

M Winkle1, J L Kluiver1, A Diepstra1

  • 1Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Critical Reviews in Oncology/Hematology
|December 5, 2017
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial in B-cell development and cancer. Their dysregulation in B-cell malignancies highlights their role in oncogenic pathways and therapeutic response, making them potential biomarkers.

Keywords:
B-cell developmentB-cell lymphomaLong noncoding RNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Biology

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators of cellular processes, including differentiation and cancer.
  • Aberrant lncRNA expression is linked to cancer hallmarks and offers potential for targeted therapies.
  • lncRNAs exhibit tissue- and cell-type specificity, making them attractive biomarkers and prognostic factors.

Purpose of the Study:

  • To review lncRNA expression changes during normal B-cell development.
  • To investigate lncRNA deregulation in B-cell malignancies.
  • To explore the prognostic value and molecular functions of deregulated lncRNAs in B-cell cancers.

Main Methods:

  • Literature review of studies on lncRNA expression in B-cell development and malignancies.
  • Analysis of lncRNA functions at transcriptional, posttranscriptional, and protein levels.
  • Evaluation of the prognostic significance and therapeutic implications of lncRNAs.

Main Results:

  • lncRNAs play essential roles in normal B-cell differentiation.
  • lncRNA deregulation is prevalent in B-cell malignancies.
  • Specific lncRNAs are implicated in oncogenic pathways and influence therapeutic responses.

Conclusions:

  • lncRNAs are major players in both normal and malignant B cells.
  • Dysregulated lncRNAs contribute to cancer development and progression.
  • lncRNAs hold promise as biomarkers and therapeutic targets in B-cell cancers.