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Ischemic complications in Takayasu's arteritis: A meta-analysis
1Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ont., Canada.
Seminars in Arthritis and Rheumatism
|December 5, 2017
Summary
Takayasu's arteritis (TAK) patients frequently experience severe ischemic complications like stroke and myocardial infarction (MI). This meta-analysis highlights the prevalence of these serious events in TAK, emphasizing the need for further research into prevention.
Area of Science:
- Cardiovascular Medicine
- Rheumatology
- Epidemiology
Background:
- Takayasu's arteritis (TAK) is a rare, large-vessel vasculitis associated with significant morbidity and mortality.
- Ischemic complications are a major concern in patients with Takayasu's arteritis.
Purpose of the Study:
- To determine the pooled proportion of Takayasu's arteritis patients experiencing severe ischemic complications.
- To quantify the prevalence of stroke and myocardial infarction in Takayasu's arteritis.
Main Methods:
- A systematic literature search was conducted across MEDLINE, EMBASE, and the Cochrane library up to March 2016.
- Included studies reported at least one severe ischemic complication in Takayasu's arteritis patients.
- A random effects model was used to estimate the pooled prevalence of complications.
Main Results:
- The meta-analysis included 35 observational studies with 3262 Takayasu's arteritis patients.
- The pooled prevalence of stroke was 8.9% and myocardial infarction was 3.4% during the disease course.
- Moderate to severe heterogeneity was observed across studies for stroke and myocardial infarction prevalence.
Conclusions:
- Stroke and myocardial infarction are common severe ischemic complications in Takayasu's arteritis.
- Further research is necessary to identify predictors and preventative strategies for these events in TAK patients.
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