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Published on: September 20, 2021
Spinal Cord Injuries and Nerve Dependence in Prostate Cancer
Alison Rutledge1, Phillip Jobling2, Marjorie M Walker3
1School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2305, Australia; Department of Surgery, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Abstract:
Nerves are emerging as drivers of tumorigenesis, as demonstrated in the mouse where denervation suppresses prostate cancer; however, clinical evidence is needed. Patients with spinal cord injuries (SCIs) resulting in functional denervation of the prostate have a lower incidence of prostate cancer. This may constitute a clinical evidence for nerve dependence in human prostate tumorigenesis.
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