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Kawasaki Disease Substantially Impacts Health-Related Quality of Life

Soultana Kourtidou1, April E Slee2, Margaret E Bruce3

  • 1Division of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

The Journal of Pediatrics
|December 5, 2017
PubMed

Insights

Children with Kawasaki disease (KD) experience significant health-related quality of life (HRQoL) decline, worse than those with cancer. Treatment response impacts HRQoL, but KD subtype does not.

Area of Science:

  • Pediatric Health
  • Quality of Life Research
  • Immunology

Background:

  • Kawasaki disease (KD) is a critical pediatric illness impacting children's well-being.
  • Health-related quality of life (HRQoL) is a crucial metric for assessing the comprehensive impact of childhood diseases.
  • Understanding the acute effects of KD on HRQoL is vital for patient management and comparative disease analysis.

Purpose of the Study:

  • To prospectively evaluate the acute impact of Kawasaki disease (KD) on health-related quality of life (HRQoL).
  • To compare the HRQoL deterioration in children with KD against other significant childhood illnesses.
  • To identify factors influencing HRQoL outcomes in pediatric KD patients.

Main Methods:

  • Prospective data merging from Outcomes Assessment Program and KD databases.
  • Utilized parent-proxy Pediatric Quality of Life Inventory (PedsQL) 4.0 for HRQoL assessment.
  • Compared KD patients (n=89) with matched cohorts of pneumonia (n=65) and newly diagnosed cancer (n=67) using ANCOVA models.

Main Results:

  • Kawasaki disease patients exhibited significantly lower PedsQL scores on admission and a greater HRQoL decline compared to cancer and pneumonia groups.
  • Non-intravenous immunoglobulin responders showed a more pronounced HRQoL decline than responders (P=.03).
  • KD diagnostic subtype and coronary artery dilatation were not significantly associated with HRQoL outcomes.

Conclusions:

  • Children with Kawasaki disease suffer acute and significant HRQoL impairment, exceeding that of newly diagnosed cancer patients.
  • Delayed treatment response in KD exacerbates HRQoL burden.
  • KD subtype and coronary artery dilatation do not appear to influence acute HRQoL outcomes.
Abstract

Keywords:
Kawasaki diseasePedsQLhealth-related quality of life

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