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How much is enough-Can resting state fMRI provide a demarcation for neurosurgical resection in glioma?
Diana C Ghinda1, Jin-Song Wu2, Niall W Duncan3
1Ottawa Hospital Research Institute, University of Ottawa, Division of Neurosurgery, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, ON, K1Y 4E9, Canada; Mind, Brain Imaging and Neuroethics, Canada Research Chair, EJLB-Michael Smith Chair for Neuroscience and Mental Health, Royal Ottawa Mental Health Centre, University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Rm. 6435, Ottawa, ON, K1Z 7K4, Canada.
Abstract:
This study represents a systematic review of the insights provided by resting state functional MRI (rs-fMRI) use in the glioma population. Following PRISMA guidelines, 45 studies were included in the review and were classified in glioma-related neuronal changes (n=28) and eloquent area localization (n=17). Despite the heterogeneous nature of the studies, there is considerable evidence of diffuse functional reorganization occurring in the setting of gliomas with local and interhemispheric functional connectivity alterations involving different functional networks. The studies showed evidence of decreased long distance functional connectivity and increased global local efficiency occurring in the setting of gliomas. The tumour grade seems to correlate with distinct functional connectivity changes. Overall, there is a potential clinical utility of rs-fMRI for identifying the functional brain network disruptions occurring in the setting of gliomas. Further studies utilizing standardized analytical methods are required to elucidate the mechanism through which gliomas induce global changes in brain connectivity.
Insights
Resting state functional MRI (rs-fMRI) reveals significant brain network changes in glioma patients. Gliomas cause diffuse functional reorganization, impacting connectivity and showing potential clinical utility for identifying disruptions.
Area of Science:
- Neuroimaging
- Neuro-oncology
- Systems Neuroscience
Background:
- Gliomas, a type of brain tumor, can induce significant alterations in brain function.
- Understanding these functional changes is crucial for surgical planning and patient management.
Purpose of the Study:
- To systematically review the insights from resting state functional MRI (rs-fMRI) in the glioma population.
- To classify studies based on their focus: glioma-related neuronal changes or eloquent area localization.
Main Methods:
- Systematic review adhering to PRISMA guidelines.
- Inclusion of 45 studies analyzing rs-fMRI data in glioma patients.
- Classification of studies into two main categories: neuronal changes (28 studies) and eloquent area localization (17 studies).
Main Results:
- Evidence of diffuse functional reorganization in glioma patients, involving local and interhemispheric connectivity alterations.
- Observed decrease in long-distance functional connectivity and increased global local efficiency associated with gliomas.
- Tumor grade appears to correlate with specific functional connectivity changes.
Conclusions:
- rs-fMRI demonstrates potential clinical utility in identifying functional brain network disruptions caused by gliomas.
- Further research with standardized analytical methods is needed to fully understand the mechanisms of glioma-induced brain connectivity changes.
