Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

4.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
4.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.4K
Overview
84.4K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.4K
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

3.5K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
3.5K
T Cell Types and Functions01:24

T Cell Types and Functions

2.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.7K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

9.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ILC2s regulate a fibroblast progenitor niche in the pancreas.

Science (New York, N.Y.)·2026
Same author

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.

Cancer cell·2026
Same author

TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures.

bioRxiv : the preprint server for biology·2026
Same author

The Spectrum of Fibroblast Immune Biology.

Annual review of immunology·2026
Same author

Reciprocal regulation of fibroblast-macrophage equilibrium governs skin integrity.

Nature immunology·2026

Related Experiment Video

Updated: Feb 17, 2026

Murine Dermal Fibroblast Isolation by FACS
06:04

Murine Dermal Fibroblast Isolation by FACS

Published on: January 7, 2016

22.6K

A short field guide to fibroblast function in immunity.

Matthew B Buechler1, Shannon J Turley1

  • 1Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, United States.

Seminars in Immunology
|December 5, 2017
PubMed
Summary
This summary is machine-generated.

Fibroblastic reticular cells (FRC) in lymphoid organs act as gate-keepers, regulating immune responses by setting up, supporting, or suppressing them. Non-lymphoid fibroblasts also influence immunity, sharing similarities and differences with FRC.

Keywords:
FibroblastFibroblastic reticular cellImmunity

More Related Videos

Ultrasonic-augmented Primary Adult Fibroblast Isolation
06:51

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

8.3K
Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
09:14

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

17.0K

Related Experiment Videos

Last Updated: Feb 17, 2026

Murine Dermal Fibroblast Isolation by FACS
06:04

Murine Dermal Fibroblast Isolation by FACS

Published on: January 7, 2016

22.6K
Ultrasonic-augmented Primary Adult Fibroblast Isolation
06:51

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

8.3K
Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
09:14

Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting

Published on: May 7, 2019

17.0K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Fibroblastic reticular cells (FRC) are crucial stromal cells within secondary lymphoid organs.
  • FRC play a significant role in orchestrating immune responses.

Purpose of the Study:

  • To elucidate the multifaceted roles of FRC in immune regulation.
  • To compare and contrast FRC with fibroblasts found in non-lymphoid tissues.
  • To highlight the emerging importance of fibroblasts in immunity.

Main Methods:

  • Literature review and synthesis of existing research on FRC and non-lymphoid fibroblasts.
  • Analysis of the mechanisms by which FRC modulate immune responses.
  • Comparative analysis of fibroblast populations.

Main Results:

  • FRC function through a three-part scheme: initiating, sustaining, or inhibiting immune responses.
  • Non-lymphoid fibroblasts share functional similarities with FRC but also exhibit distinct characteristics.
  • Both lymphoid and non-lymphoid fibroblasts are key regulators of innate and adaptive immunity.

Conclusions:

  • Fibroblasts, including FRC, are central regulators of immune responses in both lymphoid and non-lymphoid tissues.
  • Understanding fibroblast heterogeneity is critical for comprehending immune system control.
  • Further research into fibroblast roles will uncover new therapeutic targets for immune modulation.