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Triangle of AKT2, miRNA, and Tumorigenesis in Different Cancers

Maryam Honardoost1, Seyed Mohammad Ali Hosseini Rad2

  • 1Molecular Medicine, Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, No 10, Firoozeh St, Vali-asrSq, Tehran, Iran. honardoost.m@iums.ac.ir.

Applied Biochemistry and Biotechnology
|December 5, 2017
PubMed

Insights

The AKT2 oncogene drives cancer progression, invasion, and metastasis. MicroRNAs (miRNAs) regulate AKT2, offering potential as diagnostic and therapeutic cancer markers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The AKT signaling pathway, particularly its AKT2 isoform, is frequently hyperactivated in human cancers.
  • AKT2 hyperactivation promotes tumor growth, angiogenesis, metastasis, and chemoresistance.
  • AKT2 amplification and overexpression are observed across various cancer types.

Purpose of the Study:

  • To review the role of AKT2 activation in tumor progression across diverse cancers.
  • To explore the involvement of microRNAs (miRNAs) in regulating AKT2 expression in cancer.
  • To identify AKT2-related miRNAs as potential cancer biomarkers.

Main Methods:

  • In-depth literature review of studies on AKT2 and cancer.
  • Analysis of research on miRNA regulation of AKT2.
  • Synthesis of findings on AKT2's role in cancer hallmarks.

Main Results:

  • AKT2 is critically involved in cancer cell invasion, metastasis, and survival.
  • Various miRNAs have been identified that modulate AKT2 expression.
  • These AKT2-regulating miRNAs show potential as diagnostic, prognostic, and therapeutic targets.

Conclusions:

  • AKT2 hyperactivation is a key driver of malignant progression in many cancers.
  • miRNAs represent a significant regulatory mechanism for AKT2 in tumorigenesis.
  • Targeting AKT2-related miRNAs may offer novel strategies for cancer management.
Keywords:
AKT signalingAKT2CancermicroRNAs

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