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Acute hyperparathyroidism with systemic calcinosis. Report of a case
R A Khafif1, C Delima, A Silverberg
1Department of Surgery, Maimonides Medical Center, Brooklyn, NY.
Archives of Internal Medicine
|March 1, 1989
Summary
A large mediastinal parathyroid adenoma caused an acute hypercalcemic crisis, highlighting diagnostic and management challenges. Post-surgery, the patient developed rare calciphylaxis, including skin, systemic, and pulmonary calcification.
Area of Science:
- Endocrinology
- Nephrology
- Dermatology
Background:
- Parathyroid adenomas, particularly large mediastinal ones, can lead to severe hypercalcemia.
- Acute hypercalcemic crisis presents significant diagnostic and management challenges.
Observation:
- A patient presented with a massive mediastinal parathyroid adenoma precipitating an acute hypercalcemic crisis.
- Following surgical intervention, the patient developed severe calciphylaxis, a rare complication.
Findings:
- The case illustrates common pitfalls in diagnosing and managing hypercalcemic crises secondary to parathyroid adenomas.
- Postoperative calciphylaxis manifested as calcinosis cutis and widespread systemic and pulmonary calcification.
Implications:
- This case underscores the importance of vigilant monitoring and comprehensive management strategies for complex parathyroid adenoma cases.
- The occurrence of severe calciphylaxis highlights the need for further research into its pathogenesis and treatment, especially in the context of hypercalcemia.