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Antenatal vaccination to decrease pertussis in infants: safety, effectiveness, timing, and implementation

Marina Lumbreras Areta1, Christiane Sigrid Eberhardt2,3, Claire-Anne Siegrist2,4

  • 1a Department of Obstetrics and Gynecology , Geneva University Hospitals and Faculty of Medicine , Geneva , Switzerland.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|December 5, 2017
PubMed

Insights

Maternal pertussis vaccination during pregnancy is a preferred strategy to protect infants under 6 months. This antenatal immunization provides passive antibody transfer, safeguarding newborns against severe pertussis complications.

Area of Science:

  • Immunology
  • Pediatrics
  • Public Health

Background:

  • Pertussis (whooping cough) poses a significant global health threat to infants under six months.
  • Neonates and young infants are vulnerable due to their inability to be vaccinated, leading to higher risks of severe complications and mortality.

Purpose of the Study:

  • To review evidence on the safety and effectiveness of antenatal pertussis immunization.
  • To examine the optimal timing and implementation strategies for maternal pertussis vaccination.

Main Methods:

  • Systematic review of reported evidence on maternal pertussis vaccination.
  • Analysis of studies focusing on safety, effectiveness, timing, and implementation.

Main Results:

  • Maternal vaccination during pregnancy is a preferred strategy over cocooning for infant protection.
  • Passive transplacental transfer of pertussis antibodies protects newborns.

Conclusions:

  • Antenatal immunization is a key strategy for protecting vulnerable infants from pertussis.
  • Further evidence on safety, effectiveness, timing, and implementation is crucial for public health programs.

Keywords:
Immunizationmaternalpregnancysafetyvaccinationwhooping cough

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