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Transposable Elements (Human Endogenous Retroviruses) in Cancer.
Muhammad Imran Qadir1, Muhammad Usman2, Muhammad Sajid Hamid Akash3
1Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
Critical Reviews in Eukaryotic Gene Expression
|December 5, 2017
Summary
Transposable elements (TEs) are significant in cancer research, acting as regulatory elements and potential therapeutic targets. Advancements show their role in hepatocellular carcinoma pathogenesis and management.
Area of Science:
- Genomics
- Molecular Biology
- Cancer Research
Background:
- Transposable elements (TEs) are mobile DNA sequences with significant roles in genome evolution and gene regulation.
- TEs are classified into three main types based on their transposition mechanisms and structure.
- Evidence increasingly links TEs to the development and progression of various cancers.
Purpose of the Study:
- To explore the significance of transposable elements in regulatory elements research.
- To evaluate the involvement of TEs in the pathogenesis of different types of cancers.
- To highlight the potential of TEs as biomarkers and therapeutic targets in oncology.
Main Methods:
- Review of existing literature on transposable elements and cancer.
- Analysis of studies demonstrating the role of TEs in cancer development.
- Examination of research on TEs as genetic markers and therapeutic targets.
Main Results:
- Transposable elements are implicated in the regulatory mechanisms of various cancers.
- TEs can serve as valuable genetic markers for cancer detection and classification.
- TEs are involved in the pathogenesis of hepatocellular carcinoma, influencing its management.
Conclusions:
- Transposable elements are crucial players in cancer biology and regulatory networks.
- Targeting TEs offers potential for novel cancer diagnostics and therapeutics.
- Further research into TEs can advance the understanding and treatment of cancers, including hepatocellular carcinoma.
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