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Updated: Feb 17, 2026
05:17
Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
442
Targeted therapy in nonsmall cell lung cancer
1Senior Medical Advisor - Oncology, Eli Lilly and Company, Gurgaon, Haryana, India.
Indian Journal of Cancer
|December 5, 2017
Summary
Targeted therapies for non-small cell lung cancer (NSCLC) are revolutionizing treatment. Identifying specific gene mutations like EGFR and ALK allows for personalized medicine, improving patient outcomes and quality of life.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Non-small cell lung cancer (NSCLC) molecular characterization is crucial for treatment.
- Activating mutations in epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) rearrangements are key examples.
Purpose of the Study:
- To highlight the therapeutic relevance of molecular alterations in NSCLC.
- To discuss the role of genetic profiling in personalized treatment strategies.
Main Methods:
- Review of current literature on molecular characterization of NSCLC.
- Identification of key genetic alterations and their prognostic/predictive roles.
Main Results:
- EGFR mutations and ALK rearrangements are significant in adenocarcinoma.
- Other alterations like ROS, RET, MET, KRAS, DDR2, and FGFR1 are identified in different NSCLC subtypes.
- Development of targeted agents against these aberrations.
Conclusions:
- Personalized treatment strategies in NSCLC are driven by tumor biology and targeted agents.
- These advancements improve tumor control, survival, and quality of life for patients.
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