Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

16.9K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.9K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

4.0K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
4.0K
Formation of Higher-order Actin Filaments01:11

Formation of Higher-order Actin Filaments

3.7K
The polymerization of G-actin monomers into filamentous F-actin is a multi-step process. Once the F-actins are formed, they can bundle together in different arrangements to form higher-order networks and regulate cellular functions. Common examples include the formation of lamellipodia and filopodia at the cell's leading edge by actin reorganization in a migrating cell. The microvilli on the brush border epithelial cells are also formed through the F-actin network.
The high-order actin...
3.7K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

3.3K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
3.3K
Protein Folding01:22

Protein Folding

128.5K
Overview
128.5K
Protein Folding01:25

Protein Folding

11.7K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
11.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermo-osmotic flows in closed channels.

The Journal of chemical physics·2026
Same author

A density-functional theory study of vapor, liquid, and mesophases in a symmetric, hard-sphere mixture with cross attraction at non-equimolar concentrations.

The Journal of chemical physics·2025
Same author

Compositional order of a symmetric hard-sphere mixture with cross attraction: Role of concentration.

Physical review. E·2025
Same author

Vocal Markers of Schizophrenia: Assessing the Generalizability of Machine Learning Models and Their Clinical Applicability.

Schizophrenia bulletin·2025
Same author

Temperature-driven flows in nanochannels: Theory and simulations.

The Journal of chemical physics·2025
Same author

Sway frequencies may predict postural instability in Parkinson's disease: a novel convolutional neural network approach.

Journal of neuroengineering and rehabilitation·2025
Same journal

Nanopore sequencing with proteins: synchronization and dischronization of molecular dynamics simulations with laboratory and industrial developments.

Soft matter·2026
Same journal

Catanionics from biosurfactants and regular surfactants: miscibility and structure.

Soft matter·2026
Same journal

Adhesives with a thickness smaller than the fractocohesive length enhance adhesion.

Soft matter·2026
Same journal

Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies.

Soft matter·2026
Same journal

Effects of methoxy substituents on self-assembly and gelation performance of benzamide-based organogelators.

Soft matter·2026
Same journal

Rheology of <i>Escherichia coli</i> suspensions with various bacterial morphologies and motion characteristics.

Soft matter·2026
See all related articles

Related Experiment Video

Updated: Feb 17, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.5K

Pattern formation and self-assembly driven by competing interactions.

Davide Pini1, Alberto Parola

  • 1Dipartimento di Fisica, Università di Milano, Via Celoria 16, 20133 Milano, Italy. davide.pini@fisica.unimi.it.

Soft Matter
|December 5, 2017
PubMed
Summary
This summary is machine-generated.

Colloidal fluids with competing interactions form ordered mesophases instead of gas-liquid transitions. Numerical simulations reveal a rich phase diagram, including clusters, lamellae, and a novel gyroid phase.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

8.0K
Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
12:33

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

22.3K

Related Experiment Videos

Last Updated: Feb 17, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.5K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

8.0K
Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
12:33

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

22.3K

Area of Science:

  • Soft Matter Physics
  • Materials Science
  • Computational Chemistry

Background:

  • Colloidal fluids with competing short-range attraction and long-range repulsion exhibit pattern formation.
  • These interactions suppress gas-liquid phase transitions, leading to the formation of mesophases.

Purpose of the Study:

  • To numerically implement density-functional theory in 3D for periodic phases.
  • To determine the equilibrium phase diagram for colloidal fluids with competing interactions.
  • To compare the findings with existing studies on mesophase formation.

Main Methods:

  • Fully numerical implementation of density-functional theory (DFT).
  • Three-dimensional simulations tailored for periodic phases.
  • Calculation of equilibrium phase diagrams.

Main Results:

  • The model exhibits a rich phase diagram with various mesophases including clusters, bars, lamellae, inverted structures, and a bicontinuous gyroid phase.
  • The predicted phase diagram shows similarity to that of block copolymer melts.
  • A novel bicontinuous gyroid phase is identified between the bar and lamellar phases.

Conclusions:

  • Competing interactions in colloidal fluids lead to complex mesophase formation.
  • DFT simulations provide a powerful tool for predicting phase behavior in soft matter systems.
  • The discovered gyroid phase offers new possibilities for self-assembled materials.