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Precision Medicine in Pediatric Neurooncology: A Review

Aaron Y Mochizuki1, Isaura M Frost1, Melina B Mastrodimos1

  • 1Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, California 90095, United States.

ACS Chemical Neuroscience
|December 5, 2017
PubMed

Insights

Pediatric brain tumors are a leading cause of childhood cancer death. Precision medicine aims to improve treatment by targeting tumor specifics, reducing long-term side effects for better outcomes in pediatric neuro-oncology.

Area of Science:

  • Pediatric neuro-oncology
  • Cancer research
  • Precision medicine

Background:

  • Central nervous system (CNS) tumors are the primary cause of cancer-related mortality in children.
  • Current combination treatments for pediatric CNS tumors can lead to severe long-term health issues, including cognitive deficits and secondary cancers.
  • There is a critical need for more effective and less toxic treatment strategies.

Purpose of the Study:

  • To review emerging trends and current literature in pediatric neuro-oncology.
  • To highlight the development of precision medicine approaches for CNS tumors in children.
  • To discuss advancements in molecular classification, diagnostics, targeted therapies, and drug delivery systems.

Main Methods:

  • Literature review of recent studies in pediatric neuro-oncology.
  • Analysis of emerging molecularly based classification schemas.
  • Examination of novel diagnostic techniques and targeted therapeutic strategies.
  • Review of innovative drug delivery platforms for CNS tumors.

Main Results:

  • Precision medicine offers a promising avenue to selectively target tumor cells while minimizing damage to healthy tissues.
  • Molecularly based classifications are refining the understanding and treatment of pediatric CNS tumors.
  • New diagnostic tools and targeted therapies are being developed to improve treatment efficacy.
  • Advanced delivery platforms aim to enhance drug penetration and effectiveness within the CNS.

Conclusions:

  • Precision medicine strategies are revolutionizing the treatment of pediatric central nervous system tumors.
  • Targeted therapies and advanced diagnostics hold the potential to improve survival rates and reduce late effects.
  • Continued research into molecular characteristics and innovative delivery methods is crucial for advancing pediatric neuro-oncology.
Keywords:
Precision medicineneurooncologypediatricsreview

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