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Related Concept Videos

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The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
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Updated: Feb 17, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
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Brainstem network dynamics underlying the encoding of bladder information.

Anitha Manohar1, Andre L Curtis1, Stephen A Zderic1

  • 1The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, United States.

Elife
|December 5, 2017
PubMed
Summary
This summary is machine-generated.

The brain

Keywords:
Barrington's nucleusbladdercortexlocus coeruleusmicturitionneuroscienceratvoiding

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Area of Science:

  • Neuroscience
  • Urology

Background:

  • Voiding requires integration of visceral signals with arousal and attention.
  • Understanding the neural control of micturition is crucial for managing bladder dysfunction.

Purpose of the Study:

  • To investigate the central neural mechanisms coordinating bladder function with arousal and attention.
  • To elucidate the role of the pontine micturition center (PMC), locus coeruleus (LC), and medial prefrontal cortex (mPFC) in the micturition circuit.

Main Methods:

  • Multisite recordings were performed in unanesthetized rats during cystometry.
  • Neural activity was monitored in the PMC, LC, and mPFC.

Main Results:

  • PMC neurons exhibited tonic activity and phasic bursts linked to the micturition cycle.
  • LC and mPFC activation synchronized 20-30 seconds before micturition.
  • A theta oscillation emerged in the LC, mPFC desynchronized, and LC-mPFC theta coherence increased pre-micturition.

Conclusions:

  • The temporal dynamics of the LC-mPFC network suggest a preparatory role in disengaging from other behaviors and initiating micturition.
  • This neural coordination ensures appropriate timing of voiding for environmental and social contexts.