Using more than 801 296 small-molecule crystal structures to aid in protein structure refinement and analysis....

Area of Science:

• Crystallography
• Structural Biology
• Biochemistry

Background:

• The development of protein structure solution methods is crucial for understanding biological processes.
• The Cambridge Structural Database (CSD) contains a vast amount of chemical structure information.
• Previous work by Cole et al. (2017) introduced advancements in protein structure determination.

Purpose of the Study:

• To provide an addendum to the Introduction of Cole et al. (2017).
• To recognize the foundational work of Bricogne, Smart, and others.
• To highlight the significance of Cambridge Structural Database data in protein structure solution.

Main Methods:

• Review of historical contributions to crystallographic methods.
• Analysis of the impact of the Cambridge Structural Database on structural biology.
• Integration of prior research findings into the context of Cole et al. (2017).

Main Results:

• Acknowledgement of Bricogne, Smart, and colleagues' pioneering efforts.
• Recognition of the essential role of Cambridge Structural Database data.
• Contextualization of these contributions within the framework of protein structure solution.

Conclusions:

• The development of protein structure solution is a cumulative effort.
• The Cambridge Structural Database has been instrumental in advancing structural biology.
• Proper attribution is essential for scientific progress and historical accuracy.