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Updated: Dec 27, 2025

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

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High-grade Gliomas.

Lakshmi Nayak, David A Reardon

Continuum (Minneapolis, Minn.)

|December 5, 2017

Summary

This summary is machine-generated.

Standard high-grade glioma treatments like surgery, radiation, and chemotherapy are improving with new molecular insights and therapies. While outcomes remain challenging, novel strategies offer promising advancements for brain tumor patients.

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Published on: January 7, 2014

Area of Science:

Neuro-oncology
Cancer therapy
Molecular diagnostics

Background:

High-grade gliomas (HGGS) are aggressive brain tumors with limited treatment options.
Recent advancements in molecular classification are crucial for understanding HGGS.
Despite aggressive multimodal treatment, patient outcomes remain poor.

Purpose of the Study:

To review current standard treatments for high-grade gliomas.
To explore emerging therapeutic strategies and response assessment methods.
To highlight the impact of molecular markers on glioma classification and treatment.

Main Methods:

Review of current literature on high-grade glioma treatment.
Analysis of recent clinical trial data and FDA approvals.
Discussion of novel therapeutic approaches including targeted agents and immunotherapies.

Main Results:

The World Health Organization (WHO) classification now incorporates molecular markers for HGGS.
Chemotherapy (procarbazine, lomustine, vincristine) combined with radiation significantly improved survival in 1p/19q-codeleted anaplastic oligodendrogliomas.
Tumor treating fields combined with temozolomide are FDA-approved for newly diagnosed glioblastoma.

Conclusions:

Surgery, radiation, and chemotherapy are the established treatments for HGGS.
Outcomes for HGGS have seen minimal improvement over the last decade.
Advances in understanding HGGS biology are paving the way for more effective, novel therapies.