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Updated: Feb 17, 2026
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Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
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Total Synthesis of Propolisbenzofuran B
Kolluru Srinivas1, Chepuri V Ramana1
1Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune 411008, India.
Organic Letters
|December 5, 2017
Summary
Researchers developed an efficient synthesis for propolisbenzofuran B, a compound showing anticancer potential. This involved Rh-catalyzed hydroacylation and a gold-catalyzed rearrangement to build the core structure.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
- Medicinal Chemistry
Background:
- Propolisbenzofuran B is a natural product with demonstrated anticancer properties.
- Efficient synthetic routes are crucial for further investigation and potential therapeutic development.
Purpose of the Study:
- To report an efficient synthesis of propolisbenzofuran B.
- To establish a scalable method for accessing this promising anticancer natural product.
Main Methods:
- Rhodium-catalyzed intramolecular olefin hydroacylation was employed to construct the core cyclohexanone framework.
- Gold-catalyzed allenyl ether [1,3] O → C rearrangement was utilized for the synthesis of a key olefin intermediate.
Main Results:
- Successful and efficient synthesis of propolisbenzofuran B was achieved.
- The synthetic strategy effectively built the tricyclic natural product framework.
Conclusions:
- The reported synthetic route provides an efficient method for propolisbenzofuran B production.
- This synthesis facilitates further studies into the anticancer activity of propolisbenzofuran B.
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