Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

324
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
324
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.4K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.4K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

257
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
257
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

337
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
337
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

931
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
931
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

284
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
284

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Screening practices for diabetic peripheral neuropathy in pediatric type 1 diabetes: a nationwide survey by the ISPED Diabetes Study Group.

Acta diabetologica·2026
Same author

New Perspectives in Nutritional Management for Neonatal Health.

Nutrients·2026
Same author

Guidelines on diagnosis and management of gastroesophageal reflux disease in infants, children and adolescents: a joint consensus from Italian pediatric societies (SIP and SIGENP) -Part II: management.

Italian journal of pediatrics·2026
Same author

Guidelines on diagnosis and management of gastroesophageal reflux disease in infants, children and adolescents: a joint consensus from Italian pediatric societies (SIP and SIGENP) -part I. diagnosis.

Italian journal of pediatrics·2026
Same author

Ultrasonography for the positioning of esophageal multichannel intraluminal impedance/pH-metry catheter in newborns.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Identifying Predictors for the Acquisition of Tolerance to Cow's Milk Protein in Infants with Food Protein-Induced Allergic Proctocolitis (FPIAP): Multifactorial Analysis of Two Italian Cohorts.

Nutrients·2026

Related Experiment Video

Updated: Feb 17, 2026

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

1.6K

Pediatric GIST presenting as anemia.

Paola Cianci1, Chiara Luini1, Maddalena Marinoni1

  • 1a Pediatric Department , University of Insubria, Ospedale "F. Del Ponte" Varese , Italy.

Pediatric Hematology and Oncology
|December 5, 2017
PubMed
Summary

Pediatric gastrointestinal stromal tumors (GIST) are rare. This case highlights a gastric GIST in an 11-year-old girl presenting with refractory anemia, delaying diagnosis due to lack of typical GI bleeding symptoms.

Keywords:
AnemiaGISTchildrenfecal bloodgastrointestinal stromal tumor

More Related Videos

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.5K
Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine
06:09

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Published on: January 12, 2024

1.0K

Related Experiment Videos

Last Updated: Feb 17, 2026

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

1.6K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.5K
Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine
06:09

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Published on: January 12, 2024

1.0K

Area of Science:

  • Pediatric oncology
  • Gastroenterology
  • Tumor biology

Background:

  • Gastrointestinal stromal tumors (GIST) originate from interstitial cells of Cajal within the GI tract.
  • GIST are exceptionally rare in pediatric and adolescent populations.
  • Common GIST presentations include gastrointestinal bleeding, though 10-30% of cases are asymptomatic.

Observation:

  • A rare case of gastric GIST occurred in an 11-year-old girl.
  • The patient presented with iron deficiency refractory anemia.
  • Crucially, the patient exhibited no overt gastrointestinal symptoms or signs of bleeding in stool.

Findings:

  • The absence of typical bleeding symptoms led to a diagnostic delay.
  • This case underscores that GIST can manifest atypically in children.
  • Refractory anemia can be an isolated sign of GIST in pediatric patients.

Implications:

  • Highlights the importance of considering rare diagnoses like GIST in pediatric patients with unexplained refractory anemia.
  • Suggests a need for broader diagnostic considerations beyond typical GI bleeding for pediatric GIST.
  • Emphasizes the diagnostic challenges posed by asymptomatic or atypically presenting GIST in adolescents.