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Updated: Feb 17, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
[Why have we only two P53 genes?]
1Institut Necker-Enfants Malades, Inserm U1151, CNRS UMR 8253, faculté de Médecine-site Broussais, université Paris Descartes, Sorbonne Paris Cité, 14, rue Maria Helena Vieira Da Silva 75993 Paris Cedex 14, France.
Abstract:
In this forum, we develop the idea that the human genome may not be equipped to protect us after the age of reproduction against certain diseases such as cancer or neuro-degenerative diseases. We take as example cancer and show that adding one tumor suppressor in the mouse genome in its genomic context (BAC transgene) provides some protection against spontaneous and induced tumors. We also show that in certain species displaying a resistance to cancer, there is an amplification of some tumor suppressor genes.
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