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Spatially and Temporally Controlled Hydrogels for Tissue Engineering.

Jeroen Leijten1,2,3, Jungmok Seo1,2,4, Kan Yue1,2

  • 1Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

Materials Science & Engineering. R, Reports : a Review Journal
|December 5, 2017
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Summary
This summary is machine-generated.

This review highlights advances in spatiotemporal control of hydrogel biomaterials, crucial for developing functional engineered tissues. Integrating spatial and temporal techniques will drive next-generation tissue engineering.

Keywords:
BiomaterialsBioprintingCell-biomaterial interactionCellular microenvironmentsHydrogelMicrofabricationTissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Hydrogel biomaterials have seen significant advancements.
  • Spatial and temporal control over hydrogel properties is a key innovation.
  • This control is essential for developing functional engineered tissues.

Purpose of the Study:

  • To critically review emerging progress in spatiotemporal control of biomaterial properties.
  • To highlight advances in spatial and temporal control techniques for engineered tissues.
  • To discuss the integration of these techniques for next-generation tissue engineering.

Main Methods:

  • Review of spatial control techniques: surface modification, microfabrication, photo-patterning, 3D bioprinting.
  • Review of temporal control techniques: controlled release, photocleaving, controlled degradation.
  • Focus on integrating these methods for enhanced biomaterial functionality.

Main Results:

  • Significant progress in spatial control methods enables precise patterning and fabrication of hydrogels.
  • Advances in temporal control allow for dynamic modulation of hydrogel properties and functions.
  • Integration of spatial and temporal control offers unprecedented possibilities for biomaterial design.

Conclusions:

  • Spatiotemporal control is revolutionizing hydrogel biomaterials.
  • These integrated techniques are poised to drive the development of advanced engineered tissues.
  • The future of tissue engineering relies on sophisticated control over biomaterial properties.