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Related Experiment Video

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Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
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Impaired Interoceptive Accuracy in Semantic Variant Primary Progressive Aphasia.

Charles R Marshall1,2, Chris J D Hardy1, Lucy L Russell1

  • 1Dementia Research Centre, Department of Neurodegenerative Disease, London, United Kingdom.

Frontiers in Neurology
|December 5, 2017
PubMed
Summary

Interoceptive accuracy was impaired in semantic variant frontotemporal dementia patients, linking bodily sensation perception to emotional deficits and brain changes. This finding offers new insights into neurodegenerative conditions.

Keywords:
autonomiccardiacempathyfrontotemporal dementiainteroceptionprimary progressive aphasia

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Interoception, the perception of internal bodily sensations, influences emotional experience and empathy in healthy individuals.
  • Impaired interoception may underlie socioemotional deficits observed in frontotemporal dementia (FTD) syndromes.
  • The precise nature of interoceptive impairment in FTD remains unclear.

Purpose of the Study:

  • To investigate interoceptive accuracy in patients with different frontotemporal dementia syndromes.
  • To explore the relationship between interoceptive ability, emotional sensitivity, and brain structure in FTD.
  • To define the mechanisms contributing to socioemotional symptoms in neurodegenerative disorders.

Main Methods:

  • Interoceptive accuracy was measured using a heartbeat counting task in FTD patients and healthy controls.
  • Volumetric MRI and voxel-based morphometry were used to analyze brain atrophy.
  • Caregiver questionnaires assessed patients' daily-life emotional sensitivity.

Main Results:

  • Interoceptive accuracy was significantly impaired in semantic variant primary progressive aphasia (svPPA) but not in behavioral variant FTD or nonfluent variant PPA.
  • Impaired interoception correlated with reduced emotional sensitivity and atrophy in brain regions associated with interoceptive processing (insula, cingulate, amygdala) in svPPA patients.
  • These findings highlight a neural network involved in interoception and its disruption in FTD.

Conclusions:

  • Interoception offers a novel framework for understanding reduced emotional reactivity, empathy, and self-awareness in neurodegenerative conditions.
  • Objective measures of interoceptive function may help characterize complex symptoms in FTD.
  • This research provides insights into the neural basis of socioemotional deficits in FTD.