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Published on: October 19, 2014
Risk of lymphoma subtypes by occupational exposure in Southern Italy
Giovanni Maria Ferri1,2, Giorgina Specchia3, Patrizio Mazza4
1Department of Interdisciplinary Medicine (DIM), Section "B. Ramazzini", Regional University Hospital "Policlinico - Giovanni XXIII°", Unit of Occupational Medicine, University of Bari, Piazza G. Cesare, 11, 70124 Bari, Italy.
Background:
Occupational exposure is known to play a role in the aetiology of lymphomas. The aim of the present work was to explore the occupational risk of the major B-cell lymphoma subtypes using a case-control study design.
Methods:
From 2009 to 2014, we recruited 158 lymphoma cases and 76 controls in the provinces of Bari and Taranto (Apulia, Southern Italy). A retrospective assessment of occupational exposure based on complete work histories and the Carcinogen Exposure (CAREX) job-exposure matrix was performed.
Results:
After adjusting for major confounding factors, farmers showed an increased risk of diffuse large B-cell lymphoma (DLBCL) [odds ratio (OR) = 10.9 (2.3-51.6)] and multiple myeloma (MM) [OR = 16.5 (1.4-195.7)]; exposure to the fungicide Captafol was significantly associated with risk of non-Hodgkin lymphoma (NHL) [OR = 2.6 (1.1-8.2)], particularly with the risk of DLBCL [OR = 5.3 (1.6-17.3)].
Conclusions:
Agricultural activity seems to be a risk factor for developing lymphoma subtypes, particularly DLBCL, in the provinces of Bari and Taranto (Apulia Region, Southern Italy). Exposure to the pesticides Captafol, Paraquat and Radon might be implicated.
Trial Registration:
Protocol number UNIBA 2207WEJLZB_004 registered 22/09/2008.
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