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Evidence-based management of Raynaud's phenomenon
1Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester UK, M13 9PT and NIHR Manchester Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester, UK.
Therapeutic Advances in Musculoskeletal Disease
|December 5, 2017
Summary
Raynaud
Area of Science:
- Rheumatology
- Vascular Medicine
Background:
- Raynaud's phenomenon (RP) is a vascular condition often linked to connective tissue diseases.
- RP management is challenging, particularly with digital ulceration or critical ischemia.
Purpose of the Study:
- To review diagnostic approaches for identifying underlying connective tissue diseases in RP patients.
- To outline current and emerging treatment strategies for both uncomplicated and complicated RP.
Main Methods:
- Review of diagnostic criteria and the role of nailfold capillaroscopy.
- Analysis of evidence for established and novel therapeutic interventions.
Main Results:
- Nailfold capillaroscopy aids in diagnosing underlying connective tissue diseases.
- Phosphodiesterase type 5 inhibitors and endothelin 1 receptor antagonists show promise for complicated RP.
Conclusions:
- Accurate diagnosis is crucial for managing RP and associated connective tissue diseases.
- Recent therapeutic advances offer improved options for severe RP cases, with future therapies under investigation.
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