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Anti-aging effect of fullerenol on skin aging through derived stem cells in a mouse model

Wei Li1, Ning Li1, Bing Sui1

  • 1Department of Plastic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.

Experimental and Therapeutic Medicine
|December 5, 2017
PubMed

Insights

Fullerenol demonstrates anti-aging effects on skin by enhancing stem cell activity and dermal structure. Its mechanism involves regulating specific gene and protein expressions, potentially via the PPAR-γ/FoxO1 pathway.

Area of Science:

  • Biomaterials Science
  • Dermatology
  • Stem Cell Biology
  • Aging Research

Background:

  • Fullerenol, a derivative of fullerene, shares structural similarities with graphite.
  • Skin aging is a complex process influenced by cellular changes and extracellular matrix degradation.
  • Stem cells, particularly adipose-derived stem cells, play a crucial role in skin regeneration and repair.

Purpose of the Study:

  • To investigate the anti-aging effects of fullerenol on skin using a mouse model.
  • To explore the underlying mechanisms of fullerenol's action, focusing on stem cell behavior and signaling pathways.

Main Methods:

  • Assessment of fullerenol's impact on transplanted adipose-derived stem cell retention and skin structure in mice.
  • Analysis of fullerenol's effect on stem cell proliferation.
  • Evaluation of specific gene (Runt-related transcription factor 2, alkaline phosphatase, osteocalcin) and protein (PPAR-γ, FoxO1) expression changes in a D-galactose-induced skin aging mouse model.

Main Results:

  • Fullerenol treatment improved skin dermal thickness and collagen ratio while inhibiting the retention rate of transplanted stem cells.
  • Fullerenol promoted the mRNA expression of Runt-related transcription factor 2, alkaline phosphatase, and osteocalcin.
  • Fullerenol suppressed peroxisome proliferator-activated receptor-γ (PPAR-γ) protein expression and increased forkhead box protein O1 (FoxO1) protein expression.

Conclusions:

  • Fullerenol exhibits significant anti-aging properties for skin, mediated through its effects on stem cells.
  • The anti-aging mechanism of fullerenol in skin aging involves the regulation of the PPAR-γ/FoxO1 signaling pathway.
  • Fullerenol holds potential as a therapeutic agent for combating skin aging.
Keywords:
forkhead box protein O1fullerenolperoxisome proliferator-activated receptor-γskin agingstem cells

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