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Updated: Feb 17, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Synovial Sarcoma Complicating Total Knee Arthroplasty.

Olga D Savvidou¹, George D Chloros¹, Panagiotis Koutsouradis²

¹The First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Athens, Greece.

Clinics in Orthopedic Surgery

|December 5, 2017

Summary

A rare intra-articular synovial sarcoma was misdiagnosed as synovitis during knee replacement surgery. Prompt reoperation and excision led to an 8-year disease-free outcome for this soft tissue sarcoma.

Keywords:

Diagnostic errors Knee Osteoarthritis Sarcoma Synovial

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Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

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Published on: January 24, 2018

Area of Science:

Orthopedic Surgery
Oncology
Pathology

Background:

Synovial sarcoma is a periarticular soft tissue malignancy primarily affecting younger patients' extremities.
Clinical presentation can be diverse, sometimes leading to misdiagnosis and suboptimal management.
Intra-articular presentation is uncommon, posing diagnostic challenges.

Observation:

A patient undergoing total knee arthroplasty for osteoarthritis presented with an intra-operative mass.
The mass was initially misattributed to synovitis.
Subsequent biopsy confirmed a rare intra-articular synovial sarcoma.

Findings:

The patient required a second surgery involving wide excision and endoprosthesis placement.
The sarcoma was successfully treated with this aggressive surgical approach.
The patient remained disease-free for 8 years post-operatively.

Implications:

Highlights the importance of considering rare diagnoses even in common surgical settings.
Emphasizes the need for thorough pathological evaluation of unexpected intra-operative findings.
Demonstrates the potential for successful management of intra-articular synovial sarcoma with timely and appropriate intervention.