Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The history and clinical application of artificial talus in Japan.

International orthopaedics·2026
Same author

Depth of the Dorsalis Pedis Artery Distal to the First and Second Tarsometatarsal Joints: A Cadaveric Anatomical Study.

Foot & ankle orthopaedics·2026
Same author

Associations of Cognitive Impairment with Putative Glymphatic-Related Imaging Indices and Cortical Atrophy in Cerebral Amyloid Angiopathy.

Biomedicines·2026
Same author

Pain-Related Impairment and Talar Tilt as Predictors of Surgical Decision Making in Advanced Varus Ankle Osteoarthritis.

Foot & ankle orthopaedics·2026
Same author

Early neural shift detection using functional magnetic resonance imaging: a pilot study with Parkinson's disease patients undergoing istradefylline and hybrid assistive limb interventions.

Frontiers in neurology·2026
Same author

Association between individual cerebral small vessel disease MRI markers and neuropsychological performance in amnestic mild cognitive impairment: an exploratory study.

Journal of neurology·2026

Related Experiment Video

Updated: Feb 17, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K

Background and distribution of lobar microbleeds in cognitive dysfunction.

Hirofumi Matsuyama1, Yuichiro Ii1, Masayuki Maeda2

  • 1Department of Neurology Mie University Graduate School of Medicine Tsu Mie Japan.

Brain and Behavior
|December 5, 2017
PubMed
Summary

Strictly lobar cerebral microbleeds (SL-CMBs) are linked to Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), while mixed CMBs (M-CMBs) are associated with both HV and CAA in memory clinic patients.

Keywords:
cerebral amyloid angiopathycerebral microbleedshypertensive vasculopathymagnetic resonance imagingmemory clinic

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.3K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.9K

Related Experiment Videos

Last Updated: Feb 17, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.3K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.9K

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Cerebral microbleeds (CMBs) are common in memory clinic patients.
  • Deep CMBs (D-CMBs) are typically linked to hypertensive vasculopathy (HV), while strictly lobar CMBs (SL-CMBs) are associated with cerebral amyloid angiopathy (CAA), often co-occurring with Alzheimer's disease (AD).
  • Mixed CMBs (M-CMBs) are thought to result from both HV and CAA.

Purpose of the Study:

  • To differentiate between SL-CMBs and M-CMBs based on clinical characteristics and anatomical distribution.
  • To investigate the etiological underpinnings of different CMB subtypes.

Main Methods:

  • Analysis of 176 memory clinic patients using 3T-MRI with susceptibility-weighted imaging.
  • Quantification and regional density adjustment of lobar CMBs in SL-CMB and M-CMB groups.
  • Correlation of CMB location with clinical features, including dementia history, hypertension, smoking, AD, and cerebrovascular disease.

Main Results:

  • CMBs were present in 63.1% of patients; M-CMBs were most frequent (48.6%), followed by SL-CMBs (31.5%).
  • SL-CMB patients showed higher dementia history prevalence and AD, while M-CMB patients had trends toward hypertension, smoking, and co-existing AD with cerebrovascular disease.
  • M-CMBs had higher regional density in the occipital lobe, whereas SL-CMBs showed increased density in parietal and occipital lobes.

Conclusions:

  • Clinical and regional distribution differences support an etiological link between SL-CMBs and AD/CAA.
  • M-CMBs appear to be associated with both hypertensive vasculopathy (HV) and cerebral amyloid angiopathy (CAA).
  • These findings aid in understanding the distinct pathologies underlying different CMB presentations.