Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rabies: ocular pathology.

M Haltia1, A Tarkkanen, T Kivelä

  • 1Helsinki University Eye Hospital, Finland.

The British Journal of Ophthalmology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

This study details the first European human rabies case from a bat bite, revealing ocular pathology. The rabies-related virus caused retinal damage and inflammation, impacting vision.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disorders of sex development: timing of diagnosis and management in a single large tertiary center.

Endocrine connections·2018
Same author

A prospective radiologic and neurologic follow-up study of 61 HIV-1 -infected subjects: early beginning and slow progression of brain atrophy.

European journal of neurology·2013
Same author

Cutis laxa in hereditary gelsolin amyloidosis.

The British journal of dermatology·2005
Same author

The normal population distribution of PRNP codon 129 polymorphism.

Acta neurologica Scandinavica·2003
Same author

Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1.

Neurobiology of disease·2002
Same author

[Year 2001 Matti Ayrapää award to Riitta Hari].

Duodecim; laaketieteellinen aikakauskirja·2002

Area of Science:

  • Ophthalmology
  • Virology
  • Neuropathology

Background:

  • Rabies, a viral disease, can be transmitted by bats.
  • Human rabies cases are rare, especially in Europe.
  • Bat-borne rabies presents unique diagnostic and pathological challenges.

Observation:

  • A 30-year-old bat scientist developed neurological symptoms seven weeks post-bat bite.
  • The patient succumbed to the illness 23 days after symptom onset.
  • Ocular pathology was examined post-mortem in this first European human bat-borne rabies case.

Findings:

  • Rabies virus antigens were detected in brain smears; the virus was rabies-related, similar to Duvenhage virus.
  • Light microscopy revealed inflammation in the ciliary body and choroid.

Related Experiment Videos

  • Retinal findings included exudate, endothelial damage, perivascular inflammation, and destruction of retinal ganglion cells.
  • Rabies-related viral antigen was identified in retinal ganglion cells via immunofluorescence.
  • Immunohistochemistry showed reactive changes in Müller's cells (glial fibrillary acidic protein expression) and absence of synaptophysin, indicating neuronal damage.

    • Implications:

    • This case highlights the potential for bat-borne rabies transmission in Europe.
    • Ocular pathology is a significant feature of this rabies variant, potentially affecting vision.
    • Understanding the neuropathology and ocular manifestations is crucial for diagnosis and management of rare rabies cases.