Study on Liver Dysfunction in Type 2 Diabetic Patients in Bangladesh

Area of Science:

• Hepatology
• Endocrinology
• Clinical Biochemistry

Background:

• Diabetes mellitus (DM) is a global epidemic, often associated with comorbidities like obesity and cardiovascular disease.
• While links to other conditions are known, the specific relationship between DM and hepatic function requires further investigation.
• Understanding liver function changes in DM is crucial for patient management and long-term outcomes.

Purpose of the Study:

• To assess the extent and nature of liver function modifications in patients with type 2 DM.
• To compare liver function test parameters between type 2 DM patients and healthy controls.

Main Methods:

• The study enrolled 100 patients with type 2 DM and 100 healthy controls.
• Key liver function tests, including bilirubin, ALT, AST, albumin, and prothrombin time, were measured.
• Statistical analysis was performed to identify significant differences between the groups.

Main Results:

• Type 2 DM patients exhibited significantly altered levels of bilirubin, ALT, AST, albumin, and prothrombin time compared to controls (p < 0.05).
• Elevated prevalence of abnormal serum bilirubin, ALT, AST, prothrombin time, and albumin was observed in DM patients.
• Serum alkaline phosphatase levels did not show a significant difference between DM patients and controls (p > 0.05).

Conclusions:

• Abnormal liver functions are prevalent in type 2 DM patients.
• The degree of liver dysfunction varies among individuals with DM.
• Considering abnormal liver function is essential for managing type 2 DM patients and predicting their long-term prognosis.