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Are Synbiotics added to the Standard Therapy to eradicate Helicobacter pylori in Children Beneficial? A Randomized
Banu N Şirvan1, Merve K Usta2, Nurav U Kizilkan3
1Department of Pediatrics, Gaziosmanpasa Taksim Education and Research Hospital, Istanbul, Turkey.
Insights
Adding a synbiotic containing Bifidobacterium animalis to standard triple therapy significantly improved Helicobacter pylori eradication rates in children. This approach also reduced antibiotic-related side effects like diarrhea and abdominal pain.
Area of Science:
- Pediatric Gastroenterology
- Microbiology
- Pharmacology
Background:
- Helicobacter pylori infection is a common cause of gastrointestinal issues in children.
- Standard triple therapy for H. pylori eradication can be associated with side effects and variable efficacy.
- Synbiotics, combining probiotics and prebiotics, may enhance eradication and mitigate adverse effects.
Purpose of the Study:
- To evaluate the efficacy of adding a Bifidobacterium animalis-containing synbiotic to standard triple therapy for H. pylori eradication in children.
- To assess the impact of synbiotic supplementation on dyspeptic symptoms and antibiotic-related side effects.
Main Methods:
- A randomized controlled study involving 100 children (aged 5-17) diagnosed with H. pylori.
- Group 1 received standard triple therapy (amoxicillin, clarithromycin, lansoprazole) plus B. animalis synbiotic for 14 days.
- Group 2 received standard triple therapy alone.
Main Results:
- H. pylori eradication was achieved in 88% of children receiving the synbiotic versus 72% in the control group (p=0.046).
- The synbiotic group experienced significantly fewer instances of abdominal pain and diarrhea.
- No significant difference was observed in the frequency of metallic taste between groups.
Conclusions:
- Supplementation with B. animalis synbiotic enhances H. pylori eradication rates in children.
- Synbiotics effectively reduce dyspeptic symptoms and improve tolerance to eradication therapy.
- Probiotic supplementation is a promising strategy to improve H. pylori treatment outcomes in pediatric populations.
Aim:
We aimed to evaluate the role of the addition of Bifidobacterium /actis-containing synbiotic to the triple therapy in the case of He/icobacter py/ori eradication, the dyspeptic symptoms, and reducing the side effects of antibiotics.
Materials And Methods:
A total of 104 children aged between 5 and 17 years, who were histopathologically diagnosed with H. py/ori were enrolled in this study, of whom 100 were included in the analysis. Patients were randomly classified into two groups. In the first group, 50 patients were administered amoxicillin + clarithromycin + lansoprazole for 14 days and B. /actis-containing synbiotic. In the second group, 50 patients were treated with the standard triple therapy. All patients were given information after completion of therapy.
Results:
H. py/ori eradication was achieved in 88% in group I who received standard therapy with additional synbiotic and 72% in group II (p = 0.046). The number of patients in the second group who suffered from abdominal pain between the 3rd and 14th day of the treatment was higher (p < 0.05). The addition of probiotics to the triple therapy significantly reduced the frequency of diarrhea, but no significant difference was detected in the frequency of metallic taste (p = 0.04, p = 0.418 respectively).
Conclusion:
The addition of synbiotic to the triple therapy is effective for eradicating H. py/ori infection in children and is usually helpful to reduce or eliminate dyspeptic symptoms like abdominal pain, diarrhea, and vomiting. This study suggest that improved tolerance to the eradication treatment also reduces the treatment failure by adding probiotics and encourages the future study using probiotic supplementation in H. py/ori treatment.How to cite this article: Şirvan BN, Usta MK, Kizilkan NU, Urganci N. Are Synbiotics added to the Standard Therapy to eradicate He/icobacter Py/ori in Children Beneficial? A Randomized Controlled Study. Euroasian J Hepato-Gastroenterol 2017;7(1):17-22.
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