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Lymphedema Associated With Primary Amyloidosis: A Case Study.

Gahee Park1, Hye Won Jeong1, Junhee Lee1

  • 1Department of Rehabilitation Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

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|December 5, 2017
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Summary

This case study highlights primary amyloidosis as a potential cause of lower extremity lymphedema. Early diagnosis through lymph node biopsy is crucial for effective treatment of this rare condition.

Keywords:
AmyloidosisLymph nodesLymphedema

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Area of Science:

  • Medicine
  • Oncology
  • Nephrology

Background:

  • Lymphedema, characterized by fluid accumulation and swelling in extremities, can arise from various causes.
  • Primary amyloidosis is a rare systemic disease involving abnormal protein deposition, often affecting multiple organs.

Purpose of the Study:

  • To report a unique case of lymphedema in a male patient caused by primary amyloidosis.
  • To emphasize the importance of considering primary amyloidosis in the differential diagnosis of unexplained lymphedema.

Main Methods:

  • A 60-year-old male patient with a 3-year history of bilateral lower extremity and scrotal lymphedema was evaluated.
  • Computed tomography (CT) scans revealed diffuse subcutaneous edema and enlarged para-aortic and inguinal lymph nodes.
  • A biopsy of an enlarged inguinal lymph node confirmed primary amyloidosis.

Main Results:

  • The patient presented with significant lymphedema of the lower extremities and scrotum.
  • Diagnostic imaging identified enlarged lymph nodes.
  • Histopathological examination of a lymph node biopsy confirmed primary amyloidosis.

Conclusions:

  • Primary amyloidosis can manifest as lymphedema of the lower extremities.
  • This case represents the first reported instance of lymphedema associated with primary amyloidosis in Asia.
  • Early consideration of primary amyloidosis in patients with idiopathic lymphedema is recommended.