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Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable.

Weidong Zhang1, Yong Zhao1, Pengfei Zhang2

  • 1State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China; College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, PR China.

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Summary
This summary is machine-generated.

Exposure to air pollutants like hydrogen sulfide (H2S) and ammonia (NH3) significantly reduces male fertility and sperm quality across generations. Combined pollutants pose greater risks to reproductive health.

Keywords:
H(2)SHeritanceMale fertilityNH(3)Spermatogenesis

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Area of Science:

  • Environmental Health
  • Reproductive Toxicology
  • Toxicology

Background:

  • Epidemiological studies link air pollution to decreased human sperm quality and fertility.
  • The specific mechanisms by which air pollutants impact male fertility remain largely unknown.
  • Ammonia (NH3) and hydrogen sulfide (H2S) are common, reactive air pollutants found free or on particulate matter.

Purpose of the Study:

  • To investigate the effects of H2S and/or NH3 exposure on male mouse fertility.
  • To elucidate the underlying mechanisms of air pollutant-induced male infertility.
  • To assess the potential for heritable impacts on fertility across generations.

Main Methods:

  • Male mice were exposed to H2S and/or NH3.
  • Fertility parameters, sperm quality, and proteins involved in spermatogenesis were evaluated.
  • Effects were assessed over two generations to determine heritability.

Main Results:

  • H2S and/or NH3 exposure decreased male fertility by 20-30% and sperm concentration by 20-40%.
  • Sperm motility decreased by 10-20%, while abnormalities increased by approximately 30%.
  • These fertility impairments were found to be inheritable and linked to disrupted spermatogenesis, independent of body weight or organ index.

Conclusions:

  • Combined exposure to H2S and NH3 significantly diminishes male fertility and sperm quality.
  • The detrimental effects on male fertility can be passed down to subsequent generations.
  • Disruption of spermatogenesis is a key mechanism, highlighting the need for greater attention to these air pollutants for public health and fertility preservation.