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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Triple negative breast cancer: Emerging therapeutic modalities and novel combination therapies

Alice Lee1, Mustafa B A Djamgoz2

  • 1Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Cancer Treatment Reviews
|December 5, 2017
PubMed

Insights

Triple negative breast cancer (TNBC) is aggressive and hard to treat. This review explores new targeted therapies and biomarkers to improve outcomes for TNBC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Triple negative breast cancer (TNBC) is an aggressive subtype lacking hormone receptors and HER2, leading to poor prognosis.
  • TNBC exhibits high rates of metastasis and the lowest survival rates among breast cancer subtypes.
  • The absence of specific molecular targets makes therapeutic development for TNBC challenging.

Purpose of the Study:

  • To review current investigational targeted treatments for TNBC.
  • To present evidence for novel biomarkers and combination therapies to enhance response rates.
  • To discuss emerging therapeutic targets in metastatic TNBC.

Main Methods:

  • Literature review of preclinical and clinical studies on TNBC targeted therapies.
  • Evaluation of molecular characterization data for identifying new therapeutic targets.
  • Analysis of evidence for biomarkers and combination strategies.

Main Results:

  • Emerging targets include PARP1, tyrosine kinases, immune-checkpoints, androgen receptor, and epigenetic proteins.
  • PARP inhibitors show promise, with olaparib demonstrating efficacy in BRCA-mutated breast cancer.
  • TNBC heterogeneity and drug resistance necessitate novel therapeutic approaches, including combination therapies.

Conclusions:

  • Targeted therapies and novel biomarkers are crucial for improving TNBC treatment outcomes.
  • Combination therapies and addressing drug resistance are key to overcoming TNBC heterogeneity.
  • Continued research into novel targets is essential for advancing metastatic TNBC treatment.
Keywords:
BiomarkersCombination therapyTargeted therapyTriple-negative breast cancer

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